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Amaryl is indicated for the treatment of type 2 diabetes mellitus, when diet, exercise and weight reduction alone are not sufficient. The basis of optimal diabetes treatment must be a controlled diet, regular physical exercise, as well as systematic control of blood sugar and glycosuria. Oral antidiabetics or insulin cannot compensate for the patient's failure to comply with the diet. The starting dose is 1 mg of glimepiride per day. If the control achieved is satisfactory, this dosage can be adopted as maintenance therapy. If control is not satisfactory, the dose should be increased based on glycemic control, gradually with an interval of approximately 1-2 weeks for each increase, up to 2, 3 or 4 mg of glimepiride per day. A dose higher than 4 mg per day of glimepiride leads to better therapeutic results only in exceptional cases. The maximum recommended dose of glimepiride is 6 mg per day.

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